Document 2951
 DOCN  M94A2951
 TI    Chronic bacterial enteropathy in AIDS.
 DT    9412
 AU    Giang TT; Kotler DP; Orenstein JM; St. Luke's/Roosevelt Hosp. Ctr., New
       York, NY 10025.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):188 (abstract no. PB0180). Unique
       Identifier : AIDSLINE ICA10/94369624
 AB    OBJECTIVE: To determine the prevalence and clinical correlations of
       adherent bacteria in intestinal biopsies. METHODS: Biopsies from 66
       HIV-infected individuals undergoing endoscopy in 1991 were reviewed
       blindly. Light and electron microscopic detection of adherent bacteria,
       their localization in the intestine, and the relationships to diarrhea,
       weight loss, PBL CD4+ count, D-xylose absorption, travel history, and
       antibiotic usage were determined. RESULTS: Adherent bacteria were seen
       in 11 of 66 people, and in no controls. The major localization was in
       the right colon. Three distinct morphologic patterns of bacterial
       adherence were observed. Patients harboring adherent bacteria were more
       likely to have diarrhea, weight loss (p < 0.005), and PBL CD4+ counts
       less than 100 (p < 0.05). D xylose malabsorption was found in 70%. There
       were no associations with foreign or domestic travel, or with antibiotic
       usage. Antibiotic therapy, produced symptomatic improvement in most
       patients, but did not change xylose absorption. CONCLUSION: Chronic
       intestinal infection with adherent bacteria may produce a clinical
       syndrome of AIDS-associated diarrhea and wasting.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  AIDS-Related
       Opportunistic Infections/*PATHOLOGY  Bacterial Adhesion/PHYSIOLOGY
       Bacterial Infections/*PATHOLOGY  Chronic Disease  Colitis/PATHOLOGY
       Diarrhea/*PATHOLOGY  Enteritis/*PATHOLOGY  Human  Intestinal
       Mucosa/PATHOLOGY  Microscopy, Electron  MEETING ABSTRACT

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